Blood pressure drug a boon for stroke patients
Sunday October 23, 2011 07:53:07 PM,
IANS
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Washington: A commonly
prescribed blood pressure lowering medication appears to kickstart
recovery after a stroke by boosting blood vessel growth.
The discovery, based on a study using rats, occurred only because
the team, led by Susan Fagan, professor of clinical and
administrative pharmacy at the University of Georgia has opened a
new path in stroke research by examining the healthy side of the
brain after a stroke.
"I'm very excited because I think we can harness the restorative
properties of the...other side of the brain - with drug
therapies," Fagan said, the journal Public Library of Science ONE
reports.
"When most researchers study stroke they compare the animal's side
of the brain that's damaged to the opposite side, assuming that
that side is normal or not affected," said Fagan, according to a
university study.
For the study, Fagan and her team induced strokes in two groups of
male Wistar rats by blocking a major artery in the brain. A third
group, did not experience strokes so that scientists could compare
healthy brain hemispheres across all groups.
One group received a single dose of saline solution; the other
received a dose of the BP drug candesartan. The third group
received no treatment.
Animals treated with candesartan displayed higher levels of growth
factors that aid with the formation of new blood vessels in the
brain, a result that confirmed that of earlier studies from the
lab.
However, the study revealed a previously unobserved phenomenon:
Different types of growth factors dominated different hemispheres
in the brain, which suggested that candesartan could have healing
properties beyond the area of damage.
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