Institute researchers have discovered a pair of molecules that
regulate the liver's production of glucose and could be the key to
Controlling the activity of these two molecules, which work
together to allow more or less glucose production, could
potentially offer a new way to lower blood sugar to treat
insulin-resistant type II diabetes, as borne out by mice studies.
(Glucose is a simple sugar energising human cells and the central
player in diabetes)
"If you control these switches, you can control the production of
glucose, which is really at the heart of the problem of type 2
diabetes," says Marc Montminy, professor and head Salk's Clayton
Foundation Labs for Peptide Biology, the journal Nature reports.
The need for new drugs is accelerating, says Montminy, as almost
26 million Americans have type II diabetes, and an estimated 79
million people are at risk of developing the condition. Diabetes
is the sixth leading cause of death in the US, and treatment costs
are estimated at $116 billion annually, according to a Salk
In order to develop new and effective treatments for diabetes,
researchers need to understand the complex and delicate biology
behind human metabolism as well as the disorders that develop when
this finely tuned system is out of balance, Montminy says.
During the day, humans burn glucose, derived from the food we eat,
the fuel that supplies the muscles and other parts of the body
expending energy. At night, when we sleep, we revert to stored fat
as a source of very dependable but slowly released energy.
But certain parts of the body, most notably the brain, require
glucose as a source of energy, even when we fast.
Pancreatic islet cells control both sides of this energy equation.
Located in the pancreas, they produce glucagon, a hormone released
during fasting, to tell the liver to make glucose for use by the
This process is reversed when we feed, and when the pancreatic
islets release insulin, which tells the liver to stop making
glucose. Thus glucagon and insulin are part of a feedback system
designed to keep blood glucose at a stable level.