Nine genes found to affect bone density
Wednesday August 08, 2012 06:23:33 PM,
IANS
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Sydney: Scientists have
identified nine genes that seem to weaken or strength bone, which
could pave the way to more effective treatment for osteoporosis,
affecting millions worldwide.
Out of 100 'knockout mice,' which have a gene disabled, scientists
identified these genes that appear to weaken or strengthen bone.
Osteoporosis is a disease that leads to an increased risk of
fracture.
Peter Croucher, professor from Sydney's Garvan Institute of
Medical Research, with Duncan Bassett and Graham Williams,
professor from Imperial College London, and colleagues at the
Sanger Institute, used micro-CT and digital x-ray microradiography
to measure whether or not each of the first 100 genes impacted
upon bone.
"We wanted to see what screening the first 100 knockout mice off
the pipeline would tell us about the impact of these genes on
bone, and whether or not our approach was an effective one,"
Croucher was quoted as saying in the journal Public Library of
Science Genetics.
"The approach was successful in that we identified nine genes that
had not previously been described - each of which appeared to be
important in regulating our skeleton. This suggests that roughly
8-10 percent of all genes may be involved in some way," said
Croucher, according to a institute statement.
"At the moment, we're trying to understand the potential role of
the nine genes we've just identified. Our results suggest that if
you were to block some of them, it would result in higher bone
mass and stronger bones. We'll be making antibodies to those genes
to test our results," he added.
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