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Girls born to older mothers may develop breast
cancer
Wednesday February 08, 2012 08:23:12 AM,
IANS
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London: Girls born to mothers over 39 years and women
who were taller and thinner than the average girl prior to puberty
faced higher chances of developing breast cancer.
These findings were based on an analysis of a sample of 3,574
women aged between 45 and 68 years, assisted by the screening
programmes of seven of Spain's autonomous communities.
Although the role of breast density in breast cancer has been
known, researchers at the Carlos III Health Institute (ISCIII),
Spain, have now explored the influence of certain characteristics
on breast density, the journal Breast Cancer Research and
Treatment reports.
Breast density refers to women who have more fibrous connective
and glandular tissue than fatty tissue. It can make breast cancer
difficult for a radiologist to see on a mammogram, according to an
ISCIII statement.
Virginia Lope, researcher at the National Centre for Epidemiology
at the ISCIII, explains that "accumulated exposure to hormones
along with growth factors in the earlier stages of life when the
breasts begin to develop both condition breast tissue composition
and influence the probability of developing a tumour as an adult".
During the 2010 annual meeting of the American Association for
Cancer Research (AACR), various studies were presented that showed
that women with a mammographic density of 75 percent or above are
five times more likely to develop breast cancer in comparison to
women with a low density.
Furthermore, studies demonstrate that women who experience a
reduction in breast density over six years are less at risk than
those whose breast density remains stable.
Although breast density is clearly hereditary, other factors have
an influence. These include the age of the woman when she has her
first child and the number of children she has.
The authors conclude that "many studies used mammographic density
to investigate the possible influence of other exposures in breast
cancer risk".
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