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World's first bedside genetic test developed
Saturday March 31, 2012 10:36:59 AM,
IANS
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Toronto: Canadian
researchers have developed the world's first genetic test which
can be done at the patient's bedside with just a swab from his
cheek.
This revolutionary technology allows doctors to rapidly identify
patients with a genetic variant known as CYP2C19. Cardiac stent
patients with this variant have chances of reacting poorly to
standard anti-platelet therapy with Plavix® (clopidogrel).
The study demonstrated that tailored drug treatment therapy made
possible by the genetic testing successfully protected all of the
patients with the at-risk genetic variant from subsequent adverse
events, while 30 percent of patients treated with standard therapy
did not receive adequate protection, the journal The Lancet
reported.
"For the first time in medicine, nurses were able to perform DNA
testing at the patient's bedside. This is a significant step
towards the vision of personalized medicine," said Derek So,
interventional cardiologist at the University of Ottawa Heart
Institute (UOHI), and principal investigator of the RAPID GENE
study.
It enrolled 200 patients who were being treated with cardiac
stenting for an acute coronary syndrome (ACS). The test had a
sensitivity of 100 percent compared with DNA sequencing, according
to an UOHI statement.
ACS refers to any group of symptoms attributed to blockage of
coronary arteries. Its most common symptom is chest pain, often
radiating off the left arm or angle of the jaw, pressure-like in
character and tied with nausea and sweating.
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