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Scientists reveal why lost weight bounces
back
Thursday October 25, 2012 11:42:25 PM,
IANS
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Washington: The longer a mouse remains overweight,
the more "irreversible" obesity becomes, says a new study.
"Somewhere along the way, if obesity is allowed to continue, the
body appears to flip a switch that re-programmes to a heavier set
weight," said Malcolm J. Low, professor of molecular and
integrative physiology at the University of Michigan and senior
study author.
The research was undertaken by a joint team from the Michigan and
the Argentina-based National Council of Science and Technology (CONICET),
led by Viviana F. Bumaschny, assistant investigator at CONICET.
Their findings have shed light on one of the most frustrating
mysteries -- why weight always comes back.
"Our new animal model will be useful in pinpointing the reasons
why most adults find it exceedingly difficult to maintain
meaningful weight loss from dieting and exercise alone," Low said,
the Journal of Clinical Investigation reported.
Obesity affects more than 500 million adults and 43 million
children younger than age five, worldwide, while related illnesses
are the leading preventable cause of death, according to a
Michigan and CONICET statement.
Such individuals have a much higher risk of type-2 diabetes,
hypertension, and cardiovascular diseases.
One of the major strengths of the research was a new model of
obesity-programmed mice that allowed weight loss success to be
tracked at different stages and ages by flipping a genetic switch
that controls hunger.
Turning on the switch right after weaning prevented the mice from
overeating and ever becoming obese. Similarly, mice that remained
at a healthy weight into young adulthood by strict dieting alone
were able to maintain normal weight without dieting after turning
on the switch.
However, chronically overfed mice with the earliest onset of
obesity never completely returned to normal weight after flipping
the switch, despite marked reduction in food intake and increased
activity.
The new findings may raise questions about the long-term success
rate of severe calorie restriction and strenuous exercise used
later in life to lose weight, such as the extreme regimens seen in
the popular reality television show "The Biggest Loser."
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