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A capsule that suppresses cancer cells
Thursday February 07, 2013 12:06:46 PM,
IANS
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Washington: A tiny
capsule designed by US researchers could suppress cancers without
damaging healthy cells, shows a study.
Yi Tang, professor of chemical and bio-molecular engineering from
the University of California - Los Angeles (UCLA), study
co-author, reported developing tiny shells composed of a
water-soluble polymer that safely deliver a protein complex to the
nucleus of cancer cells to engineer their death.
The cell-destroying material, apoptin, is a protein complex
derived from an anaemia virus in birds.
This protein cargo accumulates in the nucleus of cancer cells and
signals to the cell to undergo programmed self-destruction.
The shells, about 100 nanometers across, are roughly half the size
of the smallest bug, degrade harmlessly in non-cancerous cells,
the journal Nano Today reports.
The process does not present the risk of genetic mutation posed by
gene therapies for cancer, or the risk to healthy cells caused by
chemotherapy, which does not effectively discriminate between
healthy and cancerous cells, Yi said, according to a California
statement.
"This approach is potentially a new way to treat cancer."
"It is a difficult problem to deliver the protein if we don't use
this vehicle. This is a unique way to treat cancer cells and leave
healthy cells untouched," Yi said.
Tests done on human breast cancer cell lines in lab mice showed
significant reduction in tumour growth.
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